Honors and Endowed Lectureships
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Szulman Lecture
“Imprinting Evolution: Silence and the Lambs”
University of Pittsburgh, Pittsburgh, PA, 2002. -
NCI Distinguished Seminar Lecture
“Evolution of Imprinted Cancer Susceptibility Genes”
NCI-Fredrick, Fredrick, MD, 2003. -
Nobel Symposium on Epigenetic Reprogramming in Development and Disease
“Biological Consequences of the Divergent Evolution of M6P/IGF2R Imprinting”, Stockholm, Sweden, 2004.
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Fetterman Endowed Lecture
“Epigenetic Basis of Human Health and Disease”
University of Pittsburgh, Pittsburgh, PA, 2006. -
20th Annual Roland D. Pinkham Basic Science Lectureship
“Environmental/Dietary Influences on Gene Imprinting and Consequences for Enhanced Disease Susceptibility”
Seattle, WA, 2006. -
Distinguished Achievement Award
College of Engineering, University of Wisconsin
Madison, WI, 2006. -
Robert T. Simpson Endowed Lecture in Molecular Medicine
“Epigenetics in Human Health and Disease”
Pennsylvania State University, University Park, PA, 2007. -
Featured Scientist
NOVA, ScienceNow, The DNA Files,
The People's Pharmacy. -
Person of the Year Nominee
Time Magazine, 2007.
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Esther B. O'Keeffe Charitable Foundation
Award Recipient, 2007 and 2008.
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Epigenetic Medicine Award
Recipient, 2008.
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Renaissance Weekend
Invited Participant, 2009 and 2013.
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National Academy of Sciences NRC Standing Committee
Use of Emerging Science for Environmental Health Decisions, 2009.
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Rank Prize Epigenetics Mini-Symposium
“Epigenetics, Imprinting, and Disease Susceptibility”
Invited Participant, 2009. -
American Society for Nutrition Presidential Series Lecture
“Epigenetics in Human Health and Disease”
Keynote Lecturer, New Orleans, LA, 2009. -
Charlotte Promersberger-Johnston Lecture
“Epigenetics: The Ghost in Our Genes”
Medical College of Wisconsin, Milwaukee, WI, 2009. -
STARS Lecture in Nutrition and Cancer
“Epigenetics, Nutrition, and Disease Susceptibility”
National Institutes of Health, Washington, DC, 2009. -
Smithsonian Institute Lecture
“Epigenetics: The Ghost in Our Genes”
Washington, DC, 2009. -
Patrick J.V. and Margaret Corcoran Lecture
“Epigenetics: The Ghost in Our Genes”
IU School of Medicine, Evansville, IN, 2009. -
Aspen Ideas Festival
Invited Participant, Aspen, CO, 2010.
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Washington Ideas Forum
Invited Participant, Washington, DC, 2010.
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Society of Toxicology’s Continuing Education Speaker Bureau
Invited Member, 2010.
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Benirschke Lecture
“Epigenetics: How Genes and Environment Interact”
Unversity of California – San Diego, San Diego, CA, 2011. -
Classic Paper of the Year Award
Environmental Health Perspectives (EHP), 2011.
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Nobel Assembly Epigenomics Meeting
“Environmental Epigenomics and the Developmental Origins of Adult Disease,” Stockholm, Sweden, 2011.
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Environmental Defense Fund Science Day
Invited Speaker, “Epigenetics 101,” Sausalito, CA, 2012.
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John Lee Pratt Nutrition Seminar
“Epigenetics, Nutrition, and Disease Susceptibility”
Virginia Polytechnic Institute and State University, Blacksburg, VA, 2012. -
NIH Director’s Wednesday Afternoon Lecture Series (WALS)
Invited Speaker, “Epigenetics: How Genes and Environment Interact,” 2012.
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Dorothy J. Killam Memorial Lecture
Epigenetics: How Genes and Environment Interact
Dalhousie University, Halifax, Nova Scotia Canada, 2013 -
Jean Andrews Award in Nutrition
Epigenetics: How Genes and Environment Interact
University of Texas, Austin, TX, 2014 -
Linus Pauling Award
Institute for Functional Medicine
San Fransisco, CA, 2014 -
Robert B. Church Lecture in Biotechnology
University of Calgary
Calgary, Alberta, Canada, 2014
Selected Invited Lectures
- Workshop on "Liver Cell Culture," American Tissue Culture Association, Alton Jones Cell Science Center, Lake Placid, New York, 1981.
- International meeting on "Cellular Repair of Radiation Damage: Mechanisms and Modifying Agents," Eleventh L. H. Gray Conference, Glasgow, Scotland, July, 1983.
- Symposium on the "Effect of Heat, Radiation and Pharmacological Agents on Tumor Microcirculation," Chemical modification of tumor blood flow. 34th Annual Meeting of the Radiation Research Society, 1986.
- NCI symposium on "Regulation of Growth and Differentiation in Normal, Regenerative and Neoplastic Hepatocytes", 1986.
- FASEB Summer research conference on "Neoplastic Transformation of Liver Cells", Copper Mt, Colorado, 1988.
- Experimental Radiation Oncology Conference, Oregon State University, Portland, OR, 1989.
- Symposium on the "Modification of Tumor Blood Flow for Therapeutic Gain". 37th Annual Meeting of the Radiation Research Society, 1989.
- International Symposium on the "Normal and Neoplastic Growth in Hepatology: Interface Between Basic and Clinical Science, University of Bari, Bari, Italy, 1989.
- Society of Toxicology. Target Organ Toxicity: Advanced Hepatotoxicity, "Regulation of Hepatocyte Proliferation", Miami Beach, FL. 1990.
- FASEB Summer Research Conference on “Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Copper Mt, Colorado, 1990.
- Pharmaceutical Manufacturers Association, Cell Proliferative Responses and their Implication in Drug Safety Assessment. "Regulation of Hepatocyte Proliferation", Tampa, FL, 1990.
- Health & Environmental Sciences Institute 2nd workshop on Mouse Liver Tumors. "The Role of Growth Factors in Liver Tumor Promotion". Washington, D.C., 1990.
- Symposium on "Cytokines and Growth Factors in Radiation Oncology", 9th ICRR, Toronto, Canada, 1991.
- NIEHS symposium on the "Molecular Mechanisms of Carcinogenesis in Humans and Rodents", Research Triangle Park, NC, 1991.
- Health & Environmental Sciences Institute 3rd workshop on Mouse Liver Tumors (Organizer and participant), Washington, D.C., 1991.
- FASEB Summer Research Conference on “Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Snowmass Village, Colorado, 1992 (Chairman).
- US-Japan Joint Workshop on "Genetic Analysis of Hepatocarcinogenesis", Honolulu, Hawaii, 1992.
- First United European Gastroenterology Week. "The role of TGF-ß and the IGF-II/M6P receptor in liver regeneration and tumor promotion". Athens, Greece, 1992.
- Radiation Research Society Symposia on Growth Factors and Cytokines. "The Role of Growth Factors in the Repair of Normal Tissue Injury", Dallas, TX, 1993.
- AASLD Single Topic Symposium on Liver Regeneration. "The Role of TGF-ß in Liver Regeneration and Tumor Promotion", Airlie, Virginia, 1993.
- Gordon Conference: Mechanisms of Toxicity. "TGF-ß: Role in Liver Tumor Promotion and Regeneration", Meriden, NH, 1993.
- Schering Foundation Workshop on Non-Genotoxic Carcinogenesis. "Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Cambridge, England, 1993.
- EPA Symposia on Carcinogenesis and Human Risk Assessment. "Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", RTP, NC, 1993.
- 7th International Conference on Carcinogenesis and Risk Assessment. Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Austin, TX, 1993.
- FASEB Summer Research Conference on “Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways”, Copper Mt, Colorado, 1994 (Co-chairman).
- American Society of Investigative Pathology, Program Committee, 1995-1996.
- American Society for Therapeutic Radiology and Oncology, Symposium on Treatment of Intrahepatic Cancers, “Transforming Growth Factor Beta: A Predictor of Normal Tissue Toxicity, Miami, FL, 1995.
- FASEB Summer Research Conference on “Cellular and Molecular Mechanism for Liver Growth Regulation”, Snowmass Village, CO, 1996, (Co-chairman).
- The British Toxicology Society Annual Meeting on “Tumor suppressor gene imprinting and risk assessment”, Brighton, UK, 1996.
- Chinese Society for Therapeutic Radiology and Oncology, R.O.C. Annual Meeting on “M6P/IGF2 receptor: a newly identified liver tumor suppressor gene” and “Transforming growth factor-beta: predictor of radiation-induced normal tissue damage”, Taipei, Taiwan, 1997.
- Cold Spring Harbor Laboratory Meeting on “The Regulation of Liver Gene Expression in Health and Disease”, Cold Spring Harbor, NY, 1997.
- 79th Annual Meeting of The Endocrine Society, Minneapolis, MN, 1997.
- Society of Toxicology Workshop on “Mouse Liver Tumors”, Chapel Hill, NC, 1997.
- Falk Workshop on “Normal and Malignant Liver Cell Growth”, Halle, Germany, 1998.
- University of Manchester, Division of Biological Sciences Seminar Series, “Genomic Imprinting and Disease Susceptibility”, Manchester, UK, 1998.
- Radiation Research Society Meeting course on “Concepts in Carcinogenesis: Role of Imprinted Genes”, Louisville, KY, 1998.
- CASL Conference on Hepatocellular Carcinoma: Science and Practice, Niagara-on-the-Lake, Canada, 1998.
- FASEB Summer Research Conference on “Mechanisms of Liver Growth and Differentiation in Health and Disease”, Snowmass Village, CO, 1998.
- 28th Annual European Environmental Mutagen Society Meeting, Salzburg, Austria, 1998.
- Duke University/NIEHS Joint Symposium on “Genomic Imprinting and Disease Susceptibility”, Durham, NC, 1998 (Chairman and Organizer).
- NIEHS Annual Leadership Retreat, Pine Hurst, NC, 1999.
- International Genomic Imprinting Symposium, “M6P/IGF2R: An Imprinted Tumor Suppressor”, Dublin, Ireland, 1999.
- EUROTOX 2000 Meeting, “M6P/IGF2R Imprinting Evolution and Cancer”, London, UK, 2000.
- International Genomic Imprinting Symposium, “Evolution and Regulation of Imprinted Genes”, Osaka, Japan, 2001.
- SNPs & Pharmacogenomics Conference; “Using SNPs to Study the Evolution and Regulation of Imprinted Genes”, Philadelphia, PA, (Chairman), 2001.
- FASEB Summer Research Conference on Growth Factor, Receptor Tyrosine Kinases in Mitogenesis, Morphogenesis and Tumorigenesis, “Imprinting in Growth and Anti-Growth”, Snowmass Village, CO, 2001.
- AACR Symposium on Molecular Aspects of GI Cancers, “Genomic Imprinting Evolution and Cancer Susceptibility”, Seoul, Korea, 2001.
- Society for Women's Health Research symposium on Sex Begins in the Womb, “Biological Consequences of Imprinting Evolution”, Palo Alto, CA, 2002.
- NIEHS US-Japan Panel Environmental Mutagenesis and Carcinogenesis Meeting, Kauai, Hawaii, 2002.
- Imprinting and Growth Congress 2002, “Evolution of Imprinted Growth Regulatory Genes”, London, UK, 2002.
- NIH Epigenetic Mechanisms in Human Disease Meeting, “Biological Consequences of Imprinting Evolution”, Washington, D.C., 2002.
- FASEB Summer research Conference on Mechanisms of Liver Growth, Differentiation & Molecular Pathogenesis of Hepatic Diseases, "Evolution of Imprinted Liver Cancer Susceptibility Genes", Snowmass Village, CO, 2002.
- American Society of Preventive Oncology Meeting, "Imprinted Genes: Epigenetic Cancer Susceptibility Loci Modified by Early Nutrition", Philadelphia, PA, 2003.
- Environmental Mutagen Society Colon Cancer Meeting, "The Impact of the Environment on Colon Cancer," Loss of Imprinting and Cancer Susceptibility: The Good News and The Bad News,” Miami Beach, Fl, 2003.
- Aspen Cancer Conference, "Evolution of Imprinted Cancer Susceptibility Genes", Aspen, CO, 2003.
- German Genetics Society Epigenetics Conference, “Transposons and Imprinted Genes: Early Nutrition and Chronic Disease Susceptibility”, Kassel, Germany, 2003.
- XII Congress on Gestational Trophoblastic Disease, "Evolution of Imprinted Tumor Susceptibility Genes", Boston, MA, 2003.
- 2004 European Society of Human Genetics on epigenetics, "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Munich, Germany, 2004.
- Frontiers in Human Embryonic Stem Cell Course/Symposium, “Evolution of Imprinted Disease Susceptibility Genes,” Pittsburgh, PA, 2004.
- Longevity Consortium Symposium, "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," New York, NY, 2004.
- 3rd Annual Meeting of the International Society of Pharmacogenomics “From Human Genetic Variations to Prediction of Risks and Responses to the Environment,” "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Santorini Island, Greece, 2004.
- Sixth Annual Conference on Sex and Gene Expression (SAGE VI), "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Winston-Salem, NC, 2005.
- Bovine Genome Project: The Next Phase International Workshop. Panel member of session entitled "The Interface with the Biomedical Community: What are the Opportunities?", Houston, TX, 2005.
- American Society of Nutrition Meeting, Presidential Series Keynote Address, 2009.
- Rank Prize Epigenetics Mini-Symposium, “Epigenetics, Imprinting, and Disease Susceptibility,” Bowness, UK, 2009.
- Biomedica Meeting, Keynote Speaker, “Environmental Epigenomics and Disease Susceptibility,” Aachen, Germany, 2010.
- International Society for Animal Genetics, Keynote Speaker, “Epigenetics, Imprinting, and Disease Susceptibility,”, Edinburgh, Scotland, 2010.
- Nestle’s 7th International Nutrition Symposium, “Epigenetics, Nutrition and Disease Susceptibility,” Lausanne, Switzerland, 2010.
- Man in Extreme Environments Meeting, “Effect of Nutrient and Toxicological Environments on the Epigenome,” Trondheim, Norway, 2010.
- Keystone Environmental Epigenomics and Disease Susceptibility Meeting, “Evolution of Genomic Imprinting,” Asheville, NC, 2011.
- Nobel Assembly Pharmacogenomics and Epigenomics in Clinical Medicine Meeting, “Environment and Epigenomic Alterations,” Stockholm, Sweden, 2011.
- NIH Director’s WALS lecture, “Epigenetics: How Genes and Environment Interact,” Washington, DC, 2012
- Smithsonian Lecture, “Epigenetics: How Genes and Environment Interact,” Washington, DC, 2013
Conferences Organized
- FASEB Summer Research Conference: Neoplastic Transformation of Liver Cells, Copper Mountain, CO, 1988 (Co-chairman).
- FASEB Summer Research Conference: Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Copper Mountain, CO, 1990 (Co-chairman).
- FASEB Summer Research Conference: Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Snowmass Village, CO, 1992 (Chairman).
- Genomic Imprinting Symposium, Durham, NC, 1998 (Chairman).
- Environmental Epigenomics, Imprinting and Disease Susceptibility, Durham, NC, 2005 (Chairman).
- Keystone Meeting, Environmental Epigenomics and Disease Susceptibility, Asheville, NC, 2011 (Chairman).
Patents
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M6P/IGF-II Receptor Tumor Suppressor Gene
Patent Number: 5,874,222; February 23, 1999
The present invention relates, in general, to a suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.
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Cancer Prognosis with the M6P/IGF-II Receptor
Patent Number: 6,218,127; April 17, 2001
The present invention relates, in general, to cancer prognosis and, in particular, to a method of assessing the prognosis of a patient using the M6P/IGF2-II receptor.