Honors and Endowed Lectureships

Selected Invited Lectures

  1. Workshop on "Liver Cell Culture," American Tissue Culture Association, Alton Jones Cell Science Center, Lake Placid, New York, 1981.
  2. International meeting on "Cellular Repair of Radiation Damage: Mechanisms and Modifying Agents," Eleventh L. H. Gray Conference, Glasgow, Scotland, July, 1983.
  3. Symposium on the "Effect of Heat, Radiation and Pharmacological Agents on Tumor Microcirculation," Chemical modification of tumor blood flow. 34th Annual Meeting of the Radiation Research Society, 1986.
  4. NCI symposium on "Regulation of Growth and Differentiation in Normal, Regenerative and Neoplastic Hepatocytes", 1986.
  5. FASEB Summer research conference on "Neoplastic Transformation of Liver Cells", Copper Mt, Colorado, 1988.
  6. Experimental Radiation Oncology Conference, Oregon State University, Portland, OR, 1989.
  7. Symposium on the "Modification of Tumor Blood Flow for Therapeutic Gain". 37th Annual Meeting of the Radiation Research Society, 1989.
  8. International Symposium on the "Normal and Neoplastic Growth in Hepatology: Interface Between Basic and Clinical Science, University of Bari, Bari, Italy, 1989.
  9. Society of Toxicology. Target Organ Toxicity: Advanced Hepatotoxicity, "Regulation of Hepatocyte Proliferation", Miami Beach, FL. 1990.
  10. FASEB Summer Research Conference on “Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Copper Mt, Colorado, 1990.
  11. Pharmaceutical Manufacturers Association, Cell Proliferative Responses and their Implication in Drug Safety Assessment. "Regulation of Hepatocyte Proliferation", Tampa, FL, 1990.
  12. Health & Environmental Sciences Institute 2nd workshop on Mouse Liver Tumors. "The Role of Growth Factors in Liver Tumor Promotion". Washington, D.C., 1990.
  13. Symposium on "Cytokines and Growth Factors in Radiation Oncology", 9th ICRR, Toronto, Canada, 1991.
  14. NIEHS symposium on the "Molecular Mechanisms of Carcinogenesis in Humans and Rodents", Research Triangle Park, NC, 1991.
  15. Health & Environmental Sciences Institute 3rd workshop on Mouse Liver Tumors (Organizer and participant), Washington, D.C., 1991.
  16. FASEB Summer Research Conference on “Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Snowmass Village, Colorado, 1992 (Chairman).
  17. US-Japan Joint Workshop on "Genetic Analysis of Hepatocarcinogenesis", Honolulu, Hawaii, 1992.
  18. First United European Gastroenterology Week. "The role of TGF-ß and the IGF-II/M6P receptor in liver regeneration and tumor promotion". Athens, Greece, 1992.
  19. Radiation Research Society Symposia on Growth Factors and Cytokines. "The Role of Growth Factors in the Repair of Normal Tissue Injury", Dallas, TX, 1993.
  20. AASLD Single Topic Symposium on Liver Regeneration. "The Role of TGF-ß in Liver Regeneration and Tumor Promotion", Airlie, Virginia, 1993.
  21. Gordon Conference: Mechanisms of Toxicity. "TGF-ß: Role in Liver Tumor Promotion and Regeneration", Meriden, NH, 1993.
  22. Schering Foundation Workshop on Non-Genotoxic Carcinogenesis. "Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Cambridge, England, 1993.
  23. EPA Symposia on Carcinogenesis and Human Risk Assessment. "Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", RTP, NC, 1993.
  24. 7th International Conference on Carcinogenesis and Risk Assessment. Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Austin, TX, 1993.
  25. FASEB Summer Research Conference on “Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways”, Copper Mt, Colorado, 1994 (Co-chairman).
  26. American Society of Investigative Pathology, Program Committee, 1995-1996.
  27. American Society for Therapeutic Radiology and Oncology, Symposium on Treatment of Intrahepatic Cancers, “Transforming Growth Factor Beta: A Predictor of Normal Tissue Toxicity, Miami, FL, 1995.
  28. FASEB Summer Research Conference on “Cellular and Molecular Mechanism for Liver Growth Regulation”, Snowmass Village, CO, 1996, (Co-chairman).
  29. The British Toxicology Society Annual Meeting on “Tumor suppressor gene imprinting and risk assessment”, Brighton, UK, 1996.
  30. Chinese Society for Therapeutic Radiology and Oncology, R.O.C. Annual Meeting on “M6P/IGF2 receptor: a newly identified liver tumor suppressor gene” and “Transforming growth factor-beta: predictor of radiation-induced normal tissue damage”, Taipei, Taiwan, 1997.
  31. Cold Spring Harbor Laboratory Meeting on “The Regulation of Liver Gene Expression in Health and Disease”, Cold Spring Harbor, NY, 1997.
  32. 79th Annual Meeting of The Endocrine Society, Minneapolis, MN, 1997.
  33. Society of Toxicology Workshop on “Mouse Liver Tumors”, Chapel Hill, NC, 1997.
  34. Falk Workshop on “Normal and Malignant Liver Cell Growth”, Halle, Germany, 1998.
  35. University of Manchester, Division of Biological Sciences Seminar Series, “Genomic Imprinting and Disease Susceptibility”, Manchester, UK, 1998.
  36. Radiation Research Society Meeting course on “Concepts in Carcinogenesis: Role of Imprinted Genes”, Louisville, KY, 1998.
  37. CASL Conference on Hepatocellular Carcinoma: Science and Practice, Niagara-on-the-Lake, Canada, 1998.
  38. FASEB Summer Research Conference on “Mechanisms of Liver Growth and Differentiation in Health and Disease”, Snowmass Village, CO, 1998.
  39. 28th Annual European Environmental Mutagen Society Meeting, Salzburg, Austria, 1998.
  40. Duke University/NIEHS Joint Symposium on “Genomic Imprinting and Disease Susceptibility”, Durham, NC, 1998 (Chairman and Organizer).
  41. NIEHS Annual Leadership Retreat, Pine Hurst, NC, 1999.
  42. International Genomic Imprinting Symposium, “M6P/IGF2R: An Imprinted Tumor Suppressor”, Dublin, Ireland, 1999.
  43. EUROTOX 2000 Meeting, “M6P/IGF2R Imprinting Evolution and Cancer”, London, UK, 2000.
  44. International Genomic Imprinting Symposium, “Evolution and Regulation of Imprinted Genes”, Osaka, Japan, 2001.
  45. SNPs & Pharmacogenomics Conference; “Using SNPs to Study the Evolution and Regulation of Imprinted Genes”, Philadelphia, PA, (Chairman), 2001.
  46. FASEB Summer Research Conference on Growth Factor, Receptor Tyrosine Kinases in Mitogenesis, Morphogenesis and Tumorigenesis, “Imprinting in Growth and Anti-Growth”, Snowmass Village, CO, 2001.
  47. AACR Symposium on Molecular Aspects of GI Cancers, “Genomic Imprinting Evolution and Cancer Susceptibility”, Seoul, Korea, 2001.
  48. Society for Women's Health Research symposium on Sex Begins in the Womb, “Biological Consequences of Imprinting Evolution”, Palo Alto, CA, 2002.
  49. NIEHS US-Japan Panel Environmental Mutagenesis and Carcinogenesis Meeting, Kauai, Hawaii, 2002.
  50. Imprinting and Growth Congress 2002, “Evolution of Imprinted Growth Regulatory Genes”, London, UK, 2002.
  51. NIH Epigenetic Mechanisms in Human Disease Meeting, “Biological Consequences of Imprinting Evolution”, Washington, D.C., 2002.
  52. FASEB Summer research Conference on Mechanisms of Liver Growth, Differentiation & Molecular Pathogenesis of Hepatic Diseases, "Evolution of Imprinted Liver Cancer Susceptibility Genes", Snowmass Village, CO, 2002.
  53. American Society of Preventive Oncology Meeting, "Imprinted Genes: Epigenetic Cancer Susceptibility Loci Modified by Early Nutrition", Philadelphia, PA, 2003.
  54. Environmental Mutagen Society Colon Cancer Meeting, "The Impact of the Environment on Colon Cancer," Loss of Imprinting and Cancer Susceptibility: The Good News and The Bad News,” Miami Beach, Fl, 2003.
  55. Aspen Cancer Conference, "Evolution of Imprinted Cancer Susceptibility Genes", Aspen, CO, 2003.
  56. German Genetics Society Epigenetics Conference, “Transposons and Imprinted Genes: Early Nutrition and Chronic Disease Susceptibility”, Kassel, Germany, 2003.
  57. XII Congress on Gestational Trophoblastic Disease, "Evolution of Imprinted Tumor Susceptibility Genes", Boston, MA, 2003.
  58. 2004 European Society of Human Genetics on epigenetics, "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Munich, Germany, 2004.
  59. Frontiers in Human Embryonic Stem Cell Course/Symposium, “Evolution of Imprinted Disease Susceptibility Genes,” Pittsburgh, PA, 2004.
  60. Longevity Consortium Symposium, "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," New York, NY, 2004.
  61. 3rd Annual Meeting of the International Society of Pharmacogenomics “From Human Genetic Variations to Prediction of Risks and Responses to the Environment,” "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Santorini Island, Greece, 2004.
  62. Sixth Annual Conference on Sex and Gene Expression (SAGE VI), "Imprinted Genes and Transposons: Epigenomic Targets Linking Fetal Nutrition with Adult Disease Susceptibility," Winston-Salem, NC, 2005.
  63. Bovine Genome Project: The Next Phase International Workshop. Panel member of session entitled "The Interface with the Biomedical Community: What are the Opportunities?", Houston, TX, 2005.
  64. American Society of Nutrition Meeting, Presidential Series Keynote Address, 2009.
  65. Rank Prize Epigenetics Mini-Symposium, “Epigenetics, Imprinting, and Disease Susceptibility,” Bowness, UK, 2009.
  66. Biomedica Meeting, Keynote Speaker, “Environmental Epigenomics and Disease Susceptibility,” Aachen, Germany, 2010.
  67. International Society for Animal Genetics, Keynote Speaker, “Epigenetics, Imprinting, and Disease Susceptibility,”, Edinburgh, Scotland, 2010.
  68. Nestle’s 7th International Nutrition Symposium, “Epigenetics, Nutrition and Disease Susceptibility,” Lausanne, Switzerland, 2010.
  69. Man in Extreme Environments Meeting, “Effect of Nutrient and Toxicological Environments on the Epigenome,” Trondheim, Norway, 2010.
  70. Keystone Environmental Epigenomics and Disease Susceptibility Meeting, “Evolution of Genomic Imprinting,” Asheville, NC, 2011.
  71. Nobel Assembly Pharmacogenomics and Epigenomics in Clinical Medicine Meeting, “Environment and Epigenomic Alterations,” Stockholm, Sweden, 2011.
  72. NIH Director’s WALS lecture, “Epigenetics: How Genes and Environment Interact,” Washington, DC, 2012
  73. Smithsonian Lecture, “Epigenetics: How Genes and Environment Interact,” Washington, DC, 2013

Conferences Organized

  1. FASEB Summer Research Conference: Neoplastic Transformation of Liver Cells, Copper Mountain, CO, 1988 (Co-chairman).
  2. FASEB Summer Research Conference: Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Copper Mountain, CO, 1990 (Co-chairman).
  3. FASEB Summer Research Conference: Hepatic Regeneration and Carcinogenesis: Molecular and Cellular Pathways, Snowmass Village, CO, 1992 (Chairman).
  4. Genomic Imprinting Symposium, Durham, NC, 1998 (Chairman).
  5. Environmental Epigenomics, Imprinting and Disease Susceptibility, Durham, NC, 2005 (Chairman).
  6. Keystone Meeting, Environmental Epigenomics and Disease Susceptibility, Asheville, NC, 2011 (Chairman).

Patents

  1. M6P/IGF-II Receptor Tumor Suppressor Gene

    Patent Number: 5,874,222; February 23, 1999

    The present invention relates, in general, to a suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.

  2. Cancer Prognosis with the M6P/IGF-II Receptor

    Patent Number: 6,218,127; April 17, 2001

    The present invention relates, in general, to cancer prognosis and, in particular, to a method of assessing the prognosis of a patient using the M6P/IGF2-II receptor.