Newer Entries
Imprinting of PEG3
Murphy, et. al. Genomics 71:110-7 (2001)
The paternally expressed Peg3 gene in mice encodes an unusual Kruppel-type zinc finger protein implicated in critical cellular and behavioral functions including growth, apoptosis, and maternal nurturing behavior. The imprinted status of PEG3 throughout life coupled with its neural expression and putative roles in regulating cell growth suggests that PEG3 may be a susceptibility locus for cancer as well as neurobehavioral deficits.
- Duke Chronicle
January 9, 2001
Scientists discover imprinted gene on chromosome 19: a gene that...
- Duke Dialogue
January 9, 2001
Imprinted gene found on human chromosome 19: mouse version...
August 6, 2012Tweet
M6P/IGF2R imprinting evolution in mammals
Killian, et. al. Mol Cell 5:707-16 (2000)
M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the element postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. These results also suggest that these two functions evolved in a mammalian clade exclusive of monotremes.
- Duke Dialogue
April 4, 2000
Platypus and opossum studies reveal origin of genetic battle of...
- Guardian
April 4, 2000
Put in on the bill
- New Scientist
April 4, 2000
Mum versus Dad: a genetic battle is being fought inside...
August 6, 2012Tweet
