Journal Articles

  1. Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C. Lead exposure during early human development and DNA methylation of imprinted gene regulatory elements in adulthood. Environ Health Perspect 124: 666-673, 2016.
  2. Skaar DA, Jirtle RL, Analysis of imprinted gene regulation. Methods Mol Biol: 2015, [Epub ahead of print].
  3. King KE, Darrah TH, Money E, Meentemeyer R, Maguire RL, Nye MD, Michener L, Murtha AP, Jirtle R, Murphy SK, Mendez MA, Robarge W, Vengosh A, Hoyo C. Geographic clustering of elevated blood heavy metal levels in pregnant women. BMC Public Health 15: 1035, 2015.
  4. Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, Kurtzberg J, Murtha A, Jirtle RL, Schildkraut JM, Hoyo C. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. Int J Obes 9: 650-657, 2015.
  5. Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, Murtha AP, Huang Z, Schildkraut J, Overcash F, Kurtzberg J, Jirtle RL, Iversen ES, Murphy SK. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genet Epigenet 6: 37-44, 2014.
  6. JIRTLE RL. The Agouti mouse: a biosensor for environmental epigenomics studies investigating the developmental origins of health and disease. Epigenomics 6: 447-450, 2014.
  7. Hoyo C, Daltveit AK, Iversen E, Benjamin-Neelon SE, Fuemmeler B, Schildkraut J, Murtha AP, Overcash F, Vidal AC, Wang F, Huang Z, Kurtzberg J, Seewaldt V, Forman M, Jirtle RL, Murphy SK. Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. Epigenetics 9: 1120-1130, 2014.
  8. Soubry A, Hoyo C, Jirtle RL, Murphy SK. A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. Bioessays 36: 359-371, 2014.
  9. Vidal AC, Murtha AP, Murphy SK, Fortner K, Overcash F, Henry N, Schildkraut JM, Forman MR, Demark-Wahnefried W, Kurtzberg J, Jirtle RL, Hoyo C. Maternal BMI, IGF-I levels, and birth weight in African American and white infants. Int J Pediatr 2013: 191472, 2013
  10. Meyer SA, Jirtle RL. Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2b expression. Sci Signal 6, 2013.
  11. Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, Neelon SE, Fuemmeler B, Iversen E, Wang F, Kurtzberg J, Jirtle RL, Hoyo C. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int J Obes (Lond) 7: 907-913, 2013.
  12. Bernal AJ, Dolinoy DC, Huang D, Skaar DA, Weinhouse C, Jirtle RL. Adaptive radiation-induced epigenetic alterations mitigated by antioxidants. FASEB J 27: 665-671, 2013.
  13. Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, Kurtzberg J, Jirtle RL, Murphy SK, Hoyo C. Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Medicine 11: 29, 2013.
  14. Skaar DA, Li Y Bernal AJ, Hoyo C, Murphy SK, Jirtle RL. The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility. ILAR J 53: 341-358, 2012.
  15. Das R, Anderson N, Koran MI, Weidman JR, Mikkelsen TS, Kamal M, Murphy SK, Linblad-Toh K, Greally JM, Jirtle RL. Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. BMC Genomics 13: 394, 2012.
  16. Das Chakraborty R, Bernal AJ, Schoch K, Howard TD, Ip EH, Hooper SR, Keshavan MS, Jirtle RL, Shashi V. Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. Transl Psychiatry 2: e105, 2012.
  17. Liu Y, Murphy SK, Murtha AP, Fuemmeler BF, Schildkraut J, Huang Z, Overcash F, Kurtzberg J, Jirtle R, Iversen ES, Forman MR, Hoyo C. Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics 7, 2012.
  18. Perkins E, Murphy SK, Murtha AP, Schildkraut J, Jirtle RL, Demark-Wahnefried W, Forman MR, Kurtzberg J, Overcash F, Huang Z, Hoyo C. Insulin-like growth factor 2/h19 methylation at birth and risk of overweight and obesity in children. J. Pediatr. 161: 31-9, 2012.
  19. Hoyo C, Fortner K, Murtha AP, Schildkraut JM, Soubry A, Demark-Wahnefried W, Jirtle RL, Kurtzberg J, Forman MR, Overcash F, Huang Z, Murphy SK. Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. Cancer Causes Control 23: 635-45, 2012.
  20. Stone JL, McMillan RE, Skaar DA, Bradshaw JM, Jirtle RL, Sikes ML. DNA double-strand breaks relieve USF-mediated repression of Dß2 germline transcription in developing thymocytes. J. Immunol. 188: 2266-75, 2012.
  21. Murphy SK, Adigun A, Huang Z, Overcash F, Wang F, Jirtle RL, Schildkraut JM, Murtha AP, Iversen ES, Hoyo C. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene 494: 36-43, 2012.
  22. Zhou FC, Kane CJ, Smith SM. Proceedings of the 2009 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group. Alcohol 46: 101-5, 2012.
  23. Hoyo C, Murphy SK, Schildkraut JM, Vidal AC, Skaar D, Millikan RC, Galanko J, Sandler RS, Jirtle R, Keku T. IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites. Dis. Markers 32: 133-41, 2012.
  24. Soubry A, Murphy S, Huang Z, Murtha A, Schildkraut J, Jirtle R, Wang F, Kurtzberg J, Demark-Wahnefried W, Forman M, Hoyo C. The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. Clin Epigenetics 3: 2, 2011.
  25. Weinhouse C, Anderson OS, Jones TR, Kim J, Liberman SA, Nahar MS, Rozek LS, Jirtle RL, Dolinoy DC. An expression microarray approach for the identification of metastable epialleles in the mouse genome. Epigenetics 6: 1105-13, 2011.
  26. Hoyo C, Murtha AP, Schildkraut JM, Jirtle RL, Demark-Wahnefried W, Forman MR, Iversen ES, Kurtzberg J, Overcash F, Huang Z, Murphy SK. Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. Epigenetics 6: 928-36, 2011.
  27. Zhang A, Skaar DA, Li Y, Huang D, Price TM, Murphy SK, Jirtle RL. Novel retrotransposed imprinted locus identified at human 6p25. Nucleic Acids Res. 39: 5388-400, 2011.
  28. Hoyo C, Murtha AP, Schildkraut JM, Forman MR, Calingaert B, Demark-Wahnefried W, Kurtzberg J, Jirtle RL, Murphy SK. Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). BMC Public Health 11: 46, 2011.
  29. Suh HS, Cosenza-Nashat M, Choi N, Zhao ML, Li JF, Pollard JW, Jirtle RL, Goldstein H, Lee SC. Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders. Am. J. Pathol. 177: 2446-58, 2010.
  30. Bernal AJ, Jirtle RL. Epigenomic disruption: the effects of early developmental exposures. Birth Defects Res. Part A Clin. Mol. Teratol. 88: 938-44, 2010.
  31. Dolinoy DC, Weinhouse C, Jones TR, Rozek LS, Jirtle RL. Variable histone modifications at the A(vy) metastable epiallele. Epigenetics 5: 637-44, 2010.
  32. Hoyo C, Schildkraut JM, Murphy SK, Chow WH, Vaughan TL, Risch H, Marks JR, Jirtle RL, Calingaert B, Calingeart B, Mayne S, Fraumeni J, Gammon MD. IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas. Int. J. Cancer 125: 2673-8, 2009.
  33. Jirtle RL. Epigenome: the program for human health and disease. Epigenomics 1: 13-6, 2009.
  34. Hoyo C, Murphy SK, Jirtle RL. Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. J Epidemiol Community Health 63: 683-4, 2009.
  35. Das R, Hampton DD, Jirtle RL. Imprinting evolution and human health. Mamm. Genome 20: 563-72, 2010.
  36. Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. Cancer Epidemiol. Biomarkers Prev. 18: 901-14, 2009.
  37. Jirtle RL. Interview. Epigenomics, imprinting and disease susceptibility. Pharmacogenomics 9: 1791-5, 2008.
  38. Jirtle RL. Randy L. Jirtle, PhD: epigenetics a window on gene dysregulation, disease. Interview by Bridget M. Kuehn. JAMA 299: 1249-50, 2008.
  39. Jang HS, Kang KM, Choi BO, Chai GY, Hong SC, Ha WS, Jirtle RL. Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma. World J. Gastroenterol. 14: 1394-8, 2008.
  40. Dolinoy DC, Jirtle RL. Environmental epigenomics in human health and disease. Environ. Mol. Mutagen. 49: 4-8, 2008.
  41. Luedi PP, Dietrich FS, Weidman JR, Bosko JM, Jirtle RL, Hartemink AJ. Computational and experimental identification of novel human imprinted genes. Genome Res. 17: 1723-30, 2007.
  42. Dolinoy DC, Huang D, Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc. Natl. Acad. Sci. U.S.A. 104: 13056-61, 2007.
  43. Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD, Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC, , , Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, Lindblad-Toh K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447: 167-77, 2007.
  44. Dolinoy DC, Das R, Weidman JR, Jirtle RL. Metastable epialleles, imprinting, and the fetal origins of adult diseases. Pediatr. Res. 61: 30R-37R, 2007.
  45. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet. 8: 253-62, 2007.
  46. Dolinoy DC, Weidman JR, Jirtle RL. Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod. Toxicol. 23: 297-307, 2007.
  47. Bobetsis YA, Barros SP, Lin DM, Weidman JR, Dolinoy DC, Jirtle RL, Boggess KA, Beck JD, Offenbacher S. Bacterial infection promotes DNA hypermethylation. J. Dent. Res. 86: 169-74, 2007.
  48. Weidman JR, Dolinoy DC, Murphy SK, Jirtle RL. Cancer susceptibility: epigenetic manifestation of environmental exposures. Cancer J 13: 9-16, 2007.
  49. Shevchenko AI, Zakharova IS, Elisaphenko EA, Kolesnikov NN, Whitehead S, Bird C, Ross M, Weidman JR, Jirtle RL, Karamysheva TV, Rubtsov NB, VandeBerg JL, Mazurok NA, Nesterova TB, Brockdorff N, Zakian SM. Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials. Chromosome Res. 15: 127-36, 2007.
  50. Liddle RA, Jirtle RL. Epigenetic silencing of genes in human colon cancer. Gastroenterology 131: 960-2, 2006.
  51. Abel KM, Allin MP, Jirtle RL. Schizophrenia, cancer and imprinting: early nutritional influences. Br J Psychiatry 188: 394, 2006.
  52. Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect. 114: 567-72, 2006.
  53. Nolan CM, McCarthy K, Eivers E, Jirtle RL, Byrnes L. Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish. Dev. Genes Evol. 216: 144-51, 2006.
  54. Murphy SK, Nolan CM, Huang Z, Kucera KS, Freking BA, Smith TP, Leymaster KA, Weidman JR, Jirtle RL. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure. Genome Res. 16: 340-6, 2006.
  55. Waterland RA, Lin JR, Smith CA, Jirtle RL. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum. Mol. Genet. 15: 705-16, 2006.
  56. Weidman JR, Maloney KA, Jirtle RL. Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1. Mamm. Genome 17: 157-67, 2006.
  57. Vu TH, Jirtle RL, Hoffman AR. Cross-species clues of an epigenetic imprinting regulatory code for the IGF2R gene. Cytogenet. Genome Res. 113: 202-8, 2006.
  58. Weidman JR, Dolinoy DC, Maloney KA, Cheng JF, Jirtle RL. Imprinting of opossum Igf2r in the absence of differential methylation and air. Epigenetics 1: 49-54, 2007.
  59. Hu CK, McCall S, Madden J, Huang H, Clough R, Jirtle RL, Anscher MS. Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer. Prostate Cancer Prostatic Dis. 9: 62-7, 2006.
  60. Evans HK, Weidman JR, Cowley DO, Jirtle RL. Comparative phylogenetic analysis of blcap/nnat reveals eutherian-specific imprinted gene. Mol. Biol. Evol. 22: 1740-8, 2005.
  61. Luedi PP, Hartemink AJ, Jirtle RL. Genome-wide prediction of imprinted murine genes. Genome Res. 15: 875-84, 2005.
  62. Murphy SK, Freking BA, Smith TP, Leymaster K, Nolan CM, Wylie AA, Evans HK, Jirtle RL. Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. Mamm. Genome 16: 171-83, 2005.
  63. Weidman JR, Murphy SK, Nolan CM, Dietrich FS, Jirtle RL. Phylogenetic footprint analysis of IGF2 in extant mammals. Genome Res. 14: 1726-32, 2004.
  64. Jirtle RL. IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer. Gastroenterology 126: 1190-3, 2004.
  65. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20: 63-8, 2004.
  66. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell. Biol. 23: 5293-300, 2003.
  67. Anscher MS, Marks LB, Shafman TD, Clough R, Huang H, Tisch A, Munley M, Herndon JE, Garst J, Crawford J, Jirtle RL. Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 56: 988-95, 2003.
  68. Murphy SK, Wylie AA, Coveler KJ, Cotter PD, Papenhausen PR, Sutton VR, Shaffer LG, Jirtle RL. Epigenetic detection of human chromosome 14 uniparental disomy. Hum. Mutat. 22: 92-7, 2003.
  69. Murphy SK, Jirtle RL. Imprinting evolution and the price of silence. Bioessays 25: 577-88, 2003.
  70. Dietz LG, Wylie AA, Rauen KA, Murphy SK, Jirtle RL, Cotter PD. Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay. J. Med. Genet. 40: e46, 2003.
  71. Jamieson TA, Brizel DM, Killian JK, Oka Y, Jang HS, Fu X, Clough RW, Vollmer RT, Anscher MS, Jirtle RL. M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis. BMC Cancer 3: 4, 2003.
  72. Wylie AA, Pulford DJ, McVie-Wylie AJ, Waterland RA, Evans HK, Chen YT, Nolan CM, Orton TC, Jirtle RL. Tissue-specific inactivation of murine M6P/IGF2R. Am. J. Pathol. 162: 321-8, 2003.
  73. Freking BA, Murphy SK, Wylie AA, Rhodes SJ, Keele JW, Leymaster KA, Jirtle RL, Smith TP. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. Genome Res. 12: 1496-506, 2002.
  74. Oka Y, Waterland RA, Killian JK, Nolan CM, Jang HS, Tohara K, Sakaguchi S, Yao T, Iwashita A, Yata Y, Takahara T, Sato S, Suzuki K, Masuda T, Jirtle RL. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology 35: 1153-63, 2002.
  75. Li T, Vu TH, Lee KO, Yang Y, Nguyen CV, Bui HQ, Zeng ZL, Nguyen BT, Hu JF, Murphy SK, Jirtle RL, Hoffman AR. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. J. Biol. Chem. 277: 13518-27, 2002.
  76. Evans HK, Wylie AA, Murphy SK, Jirtle RL. The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. Genomics 77: 99-104, 2001.
  77. Anscher MS, Marks LB, Shafman TD, Clough R, Huang H, Tisch A, Munley M, Herndon JE, Garst J, Crawford J, Jirtle RL. Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation. J. Clin. Oncol. 19: 3758-65, 2001.
  78. Killian JK, Nolan CM, Wylie AA, Li T, Vu TH, Hoffman AR, Jirtle RL. Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Hum. Mol. Genet. 10: 1721-8, 2001.
  79. Killian JK, Nolan CM, Stewart N, Munday BL, Andersen NA, Nicol S, Jirtle RL. Monotreme IGF2 expression and ancestral origin of genomic imprinting. J. Exp. Zool. 291: 205-12, 2001.
  80. Fu XL, Huang H, Bentel G, Clough R, Jirtle RL, Kong FM, Marks LB, Anscher MS. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. Int. J. Radiat. Oncol. Biol. Phys. 50: 899-908, 2001.
  81. Killian JK, Buckley TR, Stewart N, Munday BL, Jirtle RL. Marsupials and Eutherians reunited: genetic evidence for the Theria hypothesis of mammalian evolution. Mamm. Genome 12: 513-7, 2001.
  82. Nolan CM, Killian JK, Petitte JN, Jirtle RL. Imprint status of M6P/IGF2R and IGF2 in chickens. Dev. Genes Evol. 211: 179-83, 2001.
  83. Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. Genomics 71: 110-7, 2001.
  84. Killian JK, Oka Y, Jang HS, Fu X, Waterland RA, Sohda T, Sakaguchi S, Jirtle RL. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum. Mutat. 18: 25-31, 2001.
  85. Kong FM, Anscher MS, Sporn TA, Washington MK, Clough R, Barcellos-Hoff MH, Jirtle RL. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. Int. J. Radiat. Oncol. Biol. Phys. 49: 35-41, 2001.
  86. Wylie AA, Murphy SK, Orton TC, Jirtle RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 10: 1711-8, 2000.
  87. Dalton SR, Jirtle RL, Meyer SA. EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture. Toxicol. Appl. Pharmacol. 165: 115-26, 2000.
  88. Killian JK, Byrd JC, Jirtle JV, Munday BL, Stoskopf MK, MacDonald RG, Jirtle RL. M6P/IGF2R imprinting evolution in mammals. Mol. Cell 5: 707-16, 2000.
  89. Kong FM, Anscher MS, Washington MK, Killian JK, Jirtle RL. M6P/IGF2R is mutated in squamous cell carcinoma of the lung. Oncogene 19: 1572-8, 2000.
  90. Jirtle RL, Sander M, Barrett JC. Genomic imprinting and environmental disease susceptibility. Environ. Health Perspect. 108: 271-8, 2000.
  91. Murphy SK, Jirtle RL. Imprinted genes as potential genetic and epigenetic toxicologic targets. Environ. Health Perspect. 108 Suppl 1: 5-11, 2000.
  92. Kong F, Jirtle RL, Huang DH, Clough RW, Anscher MS. Plasma transforming growth factor-beta1 level before radiotherapy correlates with long term outcome of patients with lung carcinoma. Cancer 86: 1712-9, 1999.
  93. Devi GR, De Souza AT, Byrd JC, Jirtle RL, MacDonald RG. Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. Cancer Res. 59: 4314-9, 1999.
  94. Yan Y, Todaka N, Yamamura K, Hirano H, Gotoh S, Katoh T, Higashi K, Arai S, Murata Y, Higashi T, Jirtle RL. The occurrence of polymorphism of mannose 6-phosphate/insulin-like growth factor 2 receptor gene in laboratory and wild rats. J. UOEH 21: 199-208, 1999.
  95. Byrd JC, Devi GR, de Souza AT, Jirtle RL, MacDonald RG. Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations. J. Biol. Chem. 274: 24408-16, 1999.
  96. Jirtle RL. Genomic imprinting and cancer. Exp. Cell Res. 248: 18-24, 1999.
  97. Falls JG, Pulford DJ, Wylie AA, Jirtle RL. Genomic imprinting: implications for human disease. Am. J. Pathol. 154: 635-47, 1999.
  98. Killian JK, Jirtle RL. Genomic structure of the human M6P/IGF2 receptor. Mamm. Genome 10: 74-7, 1999.
  99. Pulford DJ, Falls JG, Killian JK, Jirtle RL. Polymorphisms, genomic imprinting and cancer susceptibility. Mutat. Res. 436: 59-67, 1999.
  100. Anscher MS, Kong FM, Andrews K, Clough R, Marks LB, Bentel G, Jirtle RL. Plasma transforming growth factor beta1 as a predictor of radiation pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 41: 1029-35, 1998.
  101. Mills JJ, Falls JG, De Souza AT, Jirtle RL. Imprinted M6p/Igf2 receptor is mutated in rat liver tumors. Oncogene 16: 2797-802, 1998.
  102. Anscher MS, Kong FM, Jirtle RL. The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy. Lung Cancer 19: 109-20, 1998.
  103. DiPaola RS, Weiss RE, Cummings KB, Kong FM, Jirtle RL, Anscher M, Gallo J, Goodin S, Thompson S, Rasheed Z, Aisner J, Todd MB. Effect of 13-cis-retinoic acid and alpha-interferon on transforming growth factor beta1 in patients with rising prostate-specific antigen. Clin. Cancer Res. 3: 1999-2004, 1997.
  104. Isfort RJ, Cody DB, Doersen CJ, Richards WG, Yoder BK, Wilkinson JE, Kier LD, Jirtle RL, Isenberg JS, Klounig JE, Woychik RP. The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene. Oncogene 15: 1797-803, 1997.
  105. Marks LB, Munley MT, Bentel GC, Zhou SM, Hollis D, Scarfone C, Sibley GS, Kong FM, Jirtle R, Jaszczak R, Coleman RE, Tapson V, Anscher M. Physical and biological predictors of changes in whole-lung function following thoracic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 39: 563-70, 1997.
  106. Yamada T, De Souza AT, Finkelstein S, Jirtle RL. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 94: 10351-5, 1997.
  107. Anscher MS, Kong FM, Marks LB, Bentel GC, Jirtle RL. Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 37: 253-8, 1997.
  108. De Souza AT, Yamada T, Mills JJ, Jirtle RL. Imprinted genes in liver carcinogenesis. FASEB J. 11: 60-7, 1997.
  109. Kong FM, Washington MK, Jirtle RL, Anscher MS. Plasma transforming growth factor-beta 1 reflects disease status in patients with lung cancer after radiotherapy: a possible tumor marker. Lung Cancer 16: 47-59, 1996.
  110. Moser GJ, Wolf DC, Harden R, Standeven AM, Mills J, Jirtle RL, Goldsworthy TL. Cell proliferation and regulation of negative growth factors in mouse liver foci. Carcinogenesis 17: 1835-40, 1996.
  111. Hankins GR, De Souza AT, Bentley RC, Patel MR, Marks JR, Iglehart JD, Jirtle RL. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene 12: 2003-9, 1996.
  112. Mansbach JM, Mills JJ, Boyer IJ, De Souza AT, Hankins GR, Jirtle RL. Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels. Carcinogenesis 17: 171-4, 1996.
  113. De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat. Genet. 11: 447-9, 1995.
  114. Barcellos-Hoff MH, Ehrhart EJ, Kalia M, Jirtle R, Flanders K, Tsang ML. Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue. Am. J. Pathol. 147: 1228-37, 1995.
  115. Song JJ, Celeste AJ, Kong FM, Jirtle RL, Rosen V, Thies RS. Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation. Endocrinology 136: 4293-7, 1995.
  116. Andersen ME, Mills JJ, Jirtle RL, Greenlee WF. Negative selection in hepatic tumor promotion in relation to cancer risk assessment. Toxicology 102: 223-37, 1995.
  117. Sue SR, Chari RS, Kong FM, Mills JJ, Fine RL, Jirtle RL, Meyers WC. Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma. Ann. Surg. 222: 171-8, 1995.
  118. Kong FM, Anscher MS, Murase T, Abbott BD, Iglehart JD, Jirtle RL. Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor. Ann. Surg. 222: 155-62, 1995.
  119. De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene 10: 1725-9, 1995.
  120. Lawrence TS, Robertson JM, Anscher MS, Jirtle RL, Ensminger WD, Fajardo LF. Hepatic toxicity resulting from cancer treatment. Int. J. Radiat. Oncol. Biol. Phys. 31: 1237-48, 1995.
  121. Anscher MS, Kong FM, Murase T, Jirtle RL. Short communication: normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGF beta. Br J Radiol 68: 331-3, 1995.
  122. Mills JJ, Chari RS, Boyer IJ, Gould MN, Jirtle RL. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res. 55: 979-83, 1995.
  123. Murase T, Anscher MS, Petros WP, Peters WP, Jirtle RL. Changes in plasma transforming growth factor beta in response to high-dose chemotherapy for stage II breast cancer: possible implications for the prevention of hepatic veno-occlusive disease and pulmonary drug toxicity. Bone Marrow Transplant. 15: 173-8, 1995.
  124. Chari RS, Price DT, Sue SR, Meyers WC, Jirtle RL. Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration. Am. J. Surg. 169: 126-31; discussion 131-2, 1995.
  125. Jirtle RL. Liver tumor promotion: a process of natural selection. Prog. Clin. Biol. Res. 391: 149-59, 1995.
  126. Reisenbichler H, Chari RS, Boyer IJ, Jirtle RL. Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors. Carcinogenesis 15: 2763-7, 1994.
  127. Anscher MS, Murase T, Prescott DM, Marks LB, Reisenbichler H, Bentel GC, Spencer D, Sherouse G, Jirtle RL. Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 30: 671-6, 1994.
  128. Reisenbichler H, Jirtle RL. BSA treatment of plasticware reduces TGF beta binding. BioTechniques 17: 675-6, 1994.
  129. Jirtle RL, Hankins GR, Reisenbichler H, Boyer IJ. Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital. Carcinogenesis 15: 1473-8, 1994.
  130. Murase T, Jirtle RL, McDonald GB. Transforming growth factor-beta plasma concentrations in patients with leukemia and lymphoma receiving chemoradiotherapy and marrow transplantation. Blood 83: 2383, 1994.
  131. Joines WT, Zhang Y, Li C, Jirtle RL. The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz. Med Phys 21: 547-50, 1994.
  132. Saperstein LA, Jirtle RL, Farouk M, Thompson HJ, Chung KS, Meyers WC. Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. Hepatology 19: 412-7, 1994.
  133. Schulte-Hermann R, Bursch W, Kraupp-Grasl B, Oberhammer F, Wagner A, Jirtle R. Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ. Health Perspect. 101 Suppl 5: 87-90, 1993.
  134. Jirtle RL, Haag JD, Ariazi EA, Gould MN. Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors. Cancer Res. 53: 3849-52, 1993.
  135. Eckl PM, Anderson-Carnahan L, Jirtle RL. Aquatic genotoxicity testing with rat hepatocytes in primary culture. I. SCE induction. Sci. Total Environ. 136: 111-9, 1993.
  136. Zhang Y, Joines WT, Jirtle RL, Samulski TV. Theoretical and measured electric field distributions within an annular phased array: consideration of source antennas. IEEE Trans Biomed Eng 40: 780-7, 1993.
  137. Anscher MS, Peters WP, Reisenbichler H, Petros WP, Jirtle RL. Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N. Engl. J. Med. 328: 1592-8, 1993.
  138. Hwang JJ, Hsia MT, Jirtle RL. Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, Wy-14,643. Mutat. Res. 286: 123-33, 1993.
  139. Bursch W, Oberhammer F, Jirtle RL, Askari M, Sedivy R, Grasl-Kraupp B, Purchio AF, Schulte-Hermann R. Transforming growth factor-beta 1 as a signal for induction of cell death by apoptosis. Br. J. Cancer 67: 531-6, 1993.
  140. Jirtle RL, Carr BI, Scott CD. Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration. J. Biol. Chem. 266: 22444-50, 1991.
  141. Jirtle RL, Meyer SA. Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression. Dig. Dis. Sci. 36: 659-68, 1991.
  142. Eckl PM, Alati T, Jirtle RL. The effects of a purified diet on sister chromatid exchange frequencies and mitotic activity in adult rat hepatocytes. Carcinogenesis 12: 643-6, 1991.
  143. Brockenbrough JS, Meyer SA, Li CX, Jirtle RL. Reversible and phorbol ester-specific defect of protein kinase C translocation in hepatocytes isolated from phenobarbital-treated rats. Cancer Res. 51: 130-6, 1991.
  144. Jirtle RL, Meyer SA, Brockenbrough JS. Liver tumor promoter phenobarbital: a biphasic modulator of hepatocyte proliferation. Prog. Clin. Biol. Res. 369: 209-16, 1991.
  145. Anscher MS, Crocker IR, Jirtle RL. Transforming growth factor-beta 1 expression in irradiated liver. Radiat. Res. 122: 77-85, 1990.
  146. Meyer SA, Gibbs TA, Jirtle RL. Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes. Cancer Res. 49: 5907-12, 1989.
  147. Joines WT, Shrivastav S, Jirtle RL. A comparison using tissue electrical properties and temperature rise to determine relative absorption of microwave power in malignant tissue. Med Phys 16: 840-4, 1990.
  148. Alati T, Eckl P, Jirtle RL. An in vitro micronucleus assay for determining the radiosensitivity of hepatocytes. Radiat. Res. 119: 562-8, 1989.
  149. Alati T, Van Cleeff M, Jirtle RL. Radiosensitivity of parenchymal hepatocytes as a function of oxygen concentration. Radiat. Res. 118: 488-501, 1989.
  150. Butterworth BE, Smith-Oliver T, Earle L, Loury DJ, White RD, Doolittle DJ, Working PK, Cattley RC, Jirtle R, Michalopoulos G. Use of primary cultures of human hepatocytes in toxicology studies. Cancer Res. 49: 1075-84, 1989.
  151. Meyer SA, Jirtle RL. Phenobarbital decreases hepatocyte EGF receptor expression independent of protein kinase C activation. Biochem. Biophys. Res. Commun. 158: 652-9, 1989.
  152. Gebhardt R, Jirtle R, Moorman AF, Lamers WH, Michalopoulos G. Induction of glutamine synthetase and transient co-expression with carbamoylphosphate synthetase in hepatocytes transplanted into fat pads of syngeneic hosts. Histochemistry 92: 337-42, 1989.
  153. Jirtle RL. Chemical modification of tumour blood flow. Int J Hyperthermia 4: 355-71, 1988.
  154. Alati T, Van Cleeff M, Strom SC, Jirtle RL. Radiation sensitivity of adult human parenchymal hepatocytes. Radiat. Res. 115: 152-60, 1988.
  155. Eckl PM, Meyer SA, Whitcombe WR, Jirtle RL. Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation. Carcinogenesis 9: 479-83, 1988.
  156. Eckl PM, Strom SC, Michalopoulos G, Jirtle RL. Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens. Carcinogenesis 8: 1077-83, 1987.
  157. Eckl PM, Whitcomb WR, Michalopoulos G, Jirtle RL. Effects of EGF and calcium on adult parenchymal hepatocyte proliferation. J. Cell. Physiol. 132: 363-6, 1987.
  158. Michalopoulos GK, Eckl PM, Cruise JL, Novicki DL, Jirtle RL. Mechanisms of rodent liver carcinogenesis. Toxicol Ind Health 3: 119-28, 1987.
  159. Jirtle RL, Michalopoulos G. Enhancement of the clonability of adult parenchymal hepatocytes with the liver tumor promoter phenobarbital. Carcinogenesis 7: 1813-7, 1986.
  160. Brooks AL, Guilmette RA, Hahn FF, Jirtle RL. Uptake and clearance of plutonium-238 from liver cells transplanted into fat pads of F344 rats. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 50: 631-9, 1986.
  161. France HG, Jirtle RL, Mansbach CM. Intracolonic WR 2721 protection of the rat colon from acute radiation injury. Gastroenterology 91: 644-50, 1986.
  162. Loury DJ, Smith-Oliver T, Strom S, Jirtle R, Michalopoulos G, Butterworth BE. Assessment of unscheduled and replicative DNA synthesis in hepatocytes treated in vivo and in vitro with unleaded gasoline or 2,2,4-trimethylpentane. Toxicol. Appl. Pharmacol. 85: 11-23, 1986.
  163. Jirtle RL, Pierce LJ, Crocker IR, Strom SC. Radiation protection of rat parenchymal hepatocytes with S-2-(3-aminopropylamino)ethylphosphorothioic acid. Radiother Oncol 4: 231-7, 1985.
  164. Shrivastav S, Joines WT, Jirtle RL. Effect of 5-hydroxytryptamine on tissue blood flow and microwave heating of rat tumors. Cancer Res. 45: 3203-8, 1985.
  165. Bone SN, Michalopoulos G, Jirtle RL. Ability of partial hepatectomy to induce gamma-glutamyltranspeptidase in regenerated and transplanted hepatocytes of Fischer 344 and Wistar-Furth rats. Cancer Res. 45: 1222-8, 1985.
  166. Rosenberg MR, Novicki DL, Jirtle RL, Novotny A, Michalopoulos G. Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine. Cancer Res. 45: 809-14, 1985.
  167. Novicki DL, Rosenberg MR, Michalopoulos G. Inhibition of DNA synthesis by chemical carcinogens in cultures of initiated and normal proliferating rat hepatocytes. Cancer Res. 45: 337-44, 1985.
  168. Butterworth BE, Bermudez E, Smith-Oliver T, Earle L, Cattley R, Martin J, Popp JA, Strom S, Jirtle R, Michalopoulos G. Lack of genotoxic activity of di(2-ethylhexyl)phthalate (DEHP) in rat and human hepatocytes. Carcinogenesis 5: 1329-35, 1984.
  169. Reddy JK, Jirtle RL, Watanabe TK, Reddy NK, Michalopoulos G, Qureshi SA. Response of hepatocytes transplanted into syngeneic hosts and heterotransplanted into athymic nude mice to peroxisome proliferators. Cancer Res. 44: 2582-9, 1984.
  170. Jirtle RL, DeLuca PM, Hinshaw WM, Gould MN. Survival of parenchymal hepatocytes irradiated with 14.3 MeV neutrons. Int. J. Radiat. Oncol. Biol. Phys. 10: 895-9, 1984.
  171. Kaelin WG, Shrivastav S, Jirtle RL. Blood flow to primary tumors and lymph node metastases in SMT-2A tumor-bearing rats following intravenous flunarizine. Cancer Res. 44: 896-9, 1984.
  172. Gould MN, Cathers LE, Clifton KH, Howard S, Jirtle RL, Mahler PA, Mulcahy RT, Thomas F. The influence of in situ repair systems on survival of several irradiated parenchymal cell types. Br. J. Cancer Suppl. 6: 191-5, 1984.
  173. Jirtle RL, Michalopoulos G, Strom SC, DeLuca PM, Gould MN. The survival of parenchymal hepatocytes irradiated with low and high LET radiation. Br. J. Cancer Suppl. 6: 197-201, 1984.
  174. Shrivastav S, Kaelin WG, Joines WT, Jirtle RL. Microwave hyperthermia and its effect on tumor blood flow in rats. Cancer Res. 43: 4665-9, 1983.
  175. Butterworth BE, Earle LL, Strom S, Jirtle R, Michalopoulos G. Induction of DNA repair in human and rat hepatocytes by 1,6-dinitropyrene. Mutat. Res. 122: 73-80, 1983.
  176. Strom SC, Jirtle RL, Michalopoulos G. Genotoxic effects of 2-acetylaminofluorene on rat and human hepatocytes. Environ. Health Perspect. 49: 165-70, 1983.
  177. Novicki DL, Jirtle RL, Michalopoulos G. Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol. In Vitro 19: 191-202, 1983.
  178. Strom SC, Novicki DL, Novotny A, Jirtle RL, Michalopoulos G. Human hepatocyte-mediated mutagenesis and DNA repair activity. Carcinogenesis 4: 683-6, 1983.
  179. Jirtle RL, McLain JR, Strom SC, Michalopoulos G. Repair of radiation damage in noncycling parenchymal hepatocytes. Br J Radiol 55: 847-51, 1982.
  180. Michalopoulos G, Cianciulli HD, Novotny AR, Kligerman AD, Strom SC, Jirtle RL. Liver regeneration studies with rat hepatocytes in primary culture. Cancer Res. 42: 4673-82, 1982.
  181. Kaelin WG, Shrivastav S, Shand DG, Jirtle RL. Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats. Cancer Res. 42: 3944-9, 1982.
  182. Jirtle RL, Michalopoulos G. Effects of partial hepatectomy on transplanted hepatocytes. Cancer Res. 42: 3000-4, 1982.
  183. Strom SC, Jirtle RL, Jones RS, Novicki DL, Rosenberg MR, Novotny A, Irons G, McLain JR, Michalopoulos G. Isolation, culture, and transplantation of human hepatocytes. J. Natl. Cancer Inst. 68: 771-8, 1982.
  184. Novicki DL, Irons GP, Strom SC, Jirtle R, Michalopoulos G. Cryopreservation of isolated rat hepatocytes. In Vitro 18: 393-9, 1982.
  185. Jirtle RL, Hinshaw WM. Estimation of malignant tissue blood flow with radioactively labelled microspheres. Eur J Cancer Clin Oncol 17: 1353-5, 1981.
  186. Jirtle RL, Michalopoulos G, McLain JR, Crowley J. Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation. Cancer Res. 41: 3512-8, 1981.
  187. Jirtle RL. Blood flow to lymphatic metastases in conscious rats. Eur J Cancer 17: 53-60, 1981.
  188. Jirtle RL, Biles C, Michalopoulos G. Morphologic and histochemical analysis of hepatocytes transplanted into syngeneic hosts. Am. J. Pathol. 101: 115-26, 1980.
  189. Joines WT, Jirtle RL, Rafal MD, Schaefer DJ. Microwave power absorption differences between normal and malignant tissue. Int. J. Radiat. Oncol. Biol. Phys. 6: 681-7, 1980.
  190. Jirtle RL, Clifton KH. Erythrokinetics in mice bearing tumours in either preirradiated or unirradiated tissue. Cell Tissue Kinet 11: 581-96, 1978.
  191. Jirtle R, Clifton KH, Rankin JH. Effects of several vasoactive drugs on the vascular resistance of MT-W9B tumors in W/Fu rats. Cancer Res. 38: 2385-90, 1978.
  192. Jirtle R, Rankin JH, Clifton KH. Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs. Br. J. Cancer 37: 1033-8, 1978.
  193. Jirtle R, Clifton KH. The effect of tumor size and host anemia on tumor cell survival after irradiation. Int. J. Radiat. Oncol. Biol. Phys. 4: 395-400, 1978.
  194. Jirtle R, Clifton KH, Rankin JH. Measurement of mammary tumor blood flow in unanesthetized rats. J. Natl. Cancer Inst. 60: 881-6, 1978.
  195. Gould MN, Jirtle R, Crowley J, Clifton KH. Reevaluation of the number of cells involved in the neutron induction of mammary neoplasms. Cancer Res. 38: 189-92, 1978.
  196. Rankin JH, Jirtle R, Phernetton TM. Anomalous responses of tumor vasculature to norepinephrine and prostaglandin E2 in the rabbit. Circ. Res. 41: 496-502, 1977.
  197. Clifton KH, Jirtle R. Mammary carcinoma cell population growth in preirradiated and unirradiated transplant sites. Viable tumor growth, vascularity, and the tumor-bed effect. Radiology 117: 459-65, 1975.
  198. Jirtle R, Clifton KH. Effect of preirradiation of the tumor bed on the relative vascular space of mouse gastric adenocarcinoma 328 and mammary adenocarcinoma CA755. Cancer Res. 33: 764-8, 1973.
  199. Jirtle R, Clifton KH. On carcinoma growth and vascular supply: a study of mouse mammary tumor strain MTG-B. Proc. Soc. Exp. Biol. Med. 138: 267-9, 1971.


  1. Jirtle RL, and Tyson FL, eds. Environmental Epigenomics in Health and Disease: Epigenetics and Complex Diseases. Heidelberg: Springer, 2013.
  2. Jirtle RL, and Tyson FL, eds. Environmental Epigenomics in Health and Disease: Epigenetics and Disease Origins. Heidelberg: Springer, 2013.
  3. Jirtle RL, ed. Liver Regeneration and Carcinogenesis: Cellular and Molecular Mechanisms. San Diego: Academic Press, 1995.

Book Chapters

  1. Jirtle RL. Epigenetics: How Genes and Environment Interact. In: Environmental Epigenomics in Health and Disease: Epigenetics and Disease Origins, (Jirtle, R.L. and Tyson, F.L., eds.), pp. 3-30, Springer, Heidelberg, Germany, 2013.
  2. Bernal AJ, Murphy SK, Jirtle RL. Mouse Models of Epigenetic Inheritance. In: Handbook of Epigenetics, (Tollefsbol T, ed.), pp. 233-249, Academic Press, 2010.
  3. Jirtle RL. Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor. In: Encyclopedia of Molecular Medicine, (Creighton TE, ed.), Wiley-Liss, Inc., New York, New York, 2002.
  4. Killian JK, Nolan CM, Jirtle RL. The evolution of genomic imprinting in Jurassic mammals. In: Genetic Resources for the Next Century. (Ryder O, ed). University of California Press, San Diego, 2002.
  5. Murphy SK, Jirtle, RL. Non-Genotoxic Causes of Cancer. In: Cancer Handbook, (Alison M, ed.), pp. 317-344, Macmillan Reference, Ltd., London, United Kingdom, 2002.
  6. Jirtle RL. Mannose 6-Phosphate Receptors. In: Encyclopedia of Molecular Biology, (Creidton TE, ed.), pp. 1441-1447, Wiley-Liss, Inc., New York, New York, 1999.
  7. Jirtle RL. Multifaceted M6P/IGF2R Liver Tumour Suppressor. In: Normal and Malignant Liver Cell Growth (Fleig W, ed.), pp. 136-140, Kluwer Academic Publishers, Dordrecht, The Netherlands, 1999.
  8. Anscher M, Barcellos-Hoff MH, Kong FM, Jirtle RL. Biological Functions of TGFß. In: TGFß and Cancer. (Benson JR, ed.), pp. 33-43, R.G. Landes Company, Austin, Texas, 1998.
  9. Kong FM, Anscher MS, Jirtle RL. Transforming Growth Factor Beta: A Plasma Tumor Marker. In: Methods in Molecular Biology: Tumor Marker Protocols. (Hanausek M, Walaszek Z, eds.), pp. 417-430, Humana Press, Totwa, New Jersey, 1998.
  10. Jirtle RL. Liver Tumor Promotion: A Process of Natural Selection. In: Growth Factors and Tumor Promotion: Implications for Risk Assessment, (Slaga TJ et al., eds.), pp. 149-159, Wiley-Liss, New York, New York, 1995.
  11. Mills JJ, Jirtle RL, Boyer IJ. Mechanisms of Liver Tumor Promotion. In: Liver Regeneration and Carcinogenesis: Cellular and Molecular Mechanisms. (Jirtle RL, ed.), pp. 199-226, Academic Press, San Diego, California, 1995.
  12. Jirtle RL. Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms. In: Non-Genotoxic Carcinogenesis, (Cockburn A, Smith LL, eds.), pp. 157-172, Springer, Verlag, Berlin, Germany, 1995.
  13. Jirtle RL, Anscher MS. The role of TGF-ß1 in the pathogenesis of radiation induced hepatic fibrosis. In: Radiation Research-A Twentieth-Century Perspective, Volume 2, (Chapman JD, Dewey WC, Whitmore GF, eds.), pp. 819-823, Academic Press, New York, New York, 1991.
  14. Jirtle RL, Meyer S, Brockenbrough, JS. Liver tumor promoter phenobarbital: A biphasic modulator of hepatocyte proliferation. In: Progress in Clinical and Biological Research, Chemically Induced Cell Proliferation: Implications for Risk Assessment, Volume 369, (Slaga TJ et al., eds.), pp. 209-216, Wiley-Liss, New York, New York, 1991.
  15. Jirtle RL, Anscher MA, Alati T. Radiation sensitivity of the liver. In: Advances in Radiation Biology, Volume 14, (Lett JT., and Altman KI, eds.), pp. 269-311, Academic Press, Orlando, FL, 1990.
  16. Michalopoulos G, Strom SC, Jirtle RL. Use of hepatocytes for studies of mutagenesis and carcinogenesis. In: Isolated and Cultured Hepatocytes, (Guillouzo A, ed.), pp. 333-352, John Libbey & Company, London, England, 1986.
  17. Jirtle RL, Michalopoulos G. In vivo clonal assay system for parenchymal hepatocytes. In: Cell Clones: Manual of Mammalian Cell Techniques, (Hendry JH, Potten CS, eds.), pp. 139-151, Churchill Livingstone, London, England, 1985.
  18. Jirtle RL, Michalopoulos G, McLain JR, Crowley J. Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation. In: Year Book of Cancer, Year Book Medical Publishers, 1984.
  19. Michalopoulos G, Strom SC, Novotny AR, Novicki DL, Jirtle RL. Human hepatocytes in primary culture: Applications in studies of human carcinogenesis. In: In Vitro Models for Human Disease: Carcinomas of Liver and Pancreas, (Weber M, ed.), CRC Press, 1984.
  20. Butterworth BE, Doolittle DJ, Working PK, Strom SC, Jirtle RL, Michalopoulos G. Chemically-induced DNA repair in rodent and human cells. In: Banbury Report 13: 101-122, 1983.